What does NAD+ stand for?

NAD+ stands for nicotinamide adenine dinucleotide, in its oxidised form. The "+" denotes the positively-charged nicotinamide ring nitrogen. NAD+ is a coenzyme present in all eukaryotic cells and functions as the principal electron carrier in cellular bioenergetics. It is technically a coenzyme, not a peptide, but is commonly supplied alongside research peptides in pen format.

Is NAD+ FDA approved?

No. NAD+ has no FDA approval as a pharmaceutical. It is supplied as a research compound for laboratory use only. NMN and NR (precursors) have been studied in human trials but have not received regulatory approval as therapeutic agents in any jurisdiction.

What research applications use NAD+?

NAD+ research applications cover cellular bioenergetics, sirtuin pathway pharmacology, age-related metabolic decline, PARP and CD38 substrate research, and the precursor pathway literature (NMN, NR comparisons). The Imai and Guarente 2014 Trends in Cell Biology review and the Mills 2016 Cell Metabolism long-term NMN paper provide widely-cited research entry points.

Longevity · Rx onlyNAD—05

NAD+ 1000

nicotinamide adenine dinucleotideThe coenzyme behind cellular energy and repair

Cellular energy and repair support — dosed in monthly cycles and scheduled by your physician alongside baseline diagnostics.

Monthly cyclesSubcutaneous penLabs at baseline · 12 wkPhysician-supervised

Check your eligibility Read the clinical reference →

The evidence½

NAD+ levels roughly halve between young adulthood and middle age. Restoring them supports the enzymes behind energy metabolism and DNA repair — the clinical evidence is emerging, and your physician will be direct about what is and isn’t established.

Candidacy

Who this is for

Adults with persistent fatigue, poor recovery, or a longevity focus — where baseline diagnostics support supplementation. Candidacy is decided by your physician against your history and labs, never by a checkout flow.

Often appropriatePersistent fatigue with unremarkable standard workupRecovery and sleep quality declining with training ageLongevity program alongside baseline diagnostics

Not appropriateActive malignancy under treatment — coordinate with your oncologist firstPregnancy or breastfeedingUnexplained fatigue without diagnosis — investigate first, treat second

Energy, not urgencyThe slow work of feeling like yourself again.

The program

How the program works

Day 0Free video consultation

A PRC-licensed physician reviews your goals, history, and whether this therapy is appropriate. If it isn't, you'll hear that instead.

Week 1Baseline labs & first dose

An at-home blood draw establishes your baseline. Your pen ships cold-chain once your physician signs the prescription.

MonthlyCycles & check-ins

Dosing runs in monthly cycles with rest weeks set by your physician, and messaging in between.

Week 12Full review

Repeat labs against your baseline. Together you decide: continue, adjust the cycle, or stop with a plan.

Included

What’s included

Single-patient pen, named prescriptioncGMP facility

Cold-chain delivery to your door1–2 days, Metro Manila

Baseline and repeat lab panelsbaseline, wk 12

Video reviews through the coursenamed physician

Sleep, training and recovery guidanceevery check-in

No prices on this site by design — your program is quoted in full after your consultation, before anything is dispensed.

Questions

Common questions

Some patients report changes in energy and sleep within the first cycle; for others it is gradual. Your physician reviews your labs and how you feel at week 12 rather than promising a date.

Find out if this fits youFree 20-min video consultation

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The science

The cell’s electron carrier

Redox cofactor

NAD+ functions as the principal electron carrier in cellular bioenergetics, cycling between oxidised (NAD+) and reduced (NADH) forms across the citric acid cycle, glycolysis, beta-oxidation, and the electron transport chain. The redox cycling is the most fundamental role and the one shared with all eukaryotic cells.

Sirtuin activation

Sirtuins (SIRT1-SIRT7) are NAD+-dependent deacetylases that regulate metabolism, DNA damage response, and gene expression. Imai and Guarente (Trends Cell Biol, 2014;24(8):464-471) reviewed how NAD+ availability is rate-limiting for sirtuin activity and how the age-related decline in tissue NAD+ contributes to age-associated metabolic dysfunction.

PARP and CD38 consumption

NAD+ is consumed (not just cycled) by poly-ADP-ribose polymerases (PARPs) during DNA damage repair and by CD38 in inflammatory signalling. The consumption pathways compete with sirtuins for NAD+ pool, providing the mechanistic basis for the "NAD+ depletion" framing common in aging biology research.

Salvage pathway and precursor research

NAD+ is regenerated from nicotinamide via the salvage pathway, with nicotinamide phosphoribosyltransferase (NAMPT) as the rate-limiting enzyme. NMN and NR are intermediates that bypass NAMPT and raise tissue NAD+ levels (Mills et al, Cell Metab, 2016;24(6):795-806).

NAD + 1000 is also searched as Nicotinamide adenine dinucleotide, NAD.